BOMBESIN RECEPTOR TARGETING PEPTIDE INCORPORATING A 1, 2, 3-TRIAZOLE GROUP IN THE BACKBONE FOR PREPARING IN VIVO DIAGNOSTIC AND THERAPEUTIC AGENTS

摘要

The invention relates to linear stabilized peptides, wherein one, two or more carboxamide functional groups located in the backbone are replaced by a 1,4-or 1,5-substituted 1,2,3- triazole, in particular, wherein the replaced carboxamide functional groups are at or near amide bond cleavage sites. These peptides have similar properties as the peptides from which they are derived, but show increased serum stability. Examples of peptides considered are receptor targeting peptides, such as regulatory peptides. Corresponding peptides carrying non-metallic radioisotopes, non-metallic and metallic dyes, paramagnetic metals, or radioactive metals are useful as diagnostic probes and/or therapeutic agents for cancer imaging and in cancer treatment.