CELL POPULATIONS HAVING IMMUNOREGULATORY ACTIVITY, METHODS FOR THE PREPARATION AND USES THEREOF

摘要

The present invention provides isolated immunomodulatory cells, populations, compositions and therapeutic uses thereof. The immunomodulatory cells of the invention have surprising efficacy in the immunomodulation of multiple sclerosis. In one embodiment said immunomodulatory cells are regulatory T-cells, in a particularly preferred embodiment said immunomodulatory cells are Foxp3+CD4+CD25+ T- reg and/or IL-10/TGF-.beta.- producing regulatory Trl cells. Methods for the preparation, expansion and/or generation of immunomodulatory cells of the invention comprises contacting a cell population comprising of MSC and/or fibroblast cells with PBLs in the presence of one or more multiple sclerosis-associated antigens.