NOVEL PEPTIDES

摘要

The present invention relates to the field of medical therapeutics, and more particularly to therapeutic peptides active in the treatment of bone-or cartilage disorders and other diseases. Provided herein is a series of novel peptides and fragments, analogs, derivatives, and variants thereof, structurally related to humanin,which have beneficial activities on cartilage tissues and/or bone tissues (including the prevention of negative effects of drugs on cartilage tissues and/or bone tissues), and in other diseases including, bone fractures, skeletal chondrodysplasias, cancers, autoimmune diseases, fibrotic diseases, inflammatory diseases, obesity, type I and type II diabetes, neurodegenerative diseases, infectious diseases, lung diseases, infertility,muscular disorders, aging,skin diseases, heart and vascular diseases and metabolic diseases.