发明名称 |
RESTRICTIVE INVERTED TERMINAL REPEATS FOR VIRAL VECTORS |
摘要 |
This invention relates to modified parvovirus inverted terminal repeats (ITRs) that do not functionally interact with wild-type large Rep proteins, synthetic Rep proteins that functionally interact with the modified ITRs, and methods of using the same for delivery of nucleic acids to a cell or a subject. The modifications provide a novel Rep-ITR interaction that limits vector mobilization, increasing the safety of viral vectors. |
申请公布号 |
EP2524037(A1) |
申请公布日期 |
2012.11.21 |
申请号 |
EP20110733293 |
申请日期 |
2011.01.12 |
申请人 |
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL |
发明人 |
HEWITT, CURTIS;SAMULSKI, RICHARD JUDE |
分类号 |
C12N15/00 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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