发明名称 |
BIOMARKERS OF IMMUNOMODULATORY EFFECTS IN HUMANS TREATED WITH ANTI-CD200 ANTIBODIES |
摘要 |
The present disclosure relates to anti-CD200 antibodies (e.g., variant anti-CD200 antibodies having decreased or no effector function) and to biomarkers for use in a variety of diagnostic and therapeutic methods, e.g., determining whether a human has been administered one or more of the antibodies at a dose sufficient to induce a desired immunomodulatory effect in the human and/or selecting an appropriate dosing schedule for a patient. |
申请公布号 |
EP2523976(A1) |
申请公布日期 |
2012.11.21 |
申请号 |
EP20110732296 |
申请日期 |
2011.01.11 |
申请人 |
ALEXION PHARMACEUTICALS, INC. |
发明人 |
FAAS MCKNIGHT, SUSAN;COFIELL, ROXANNE;YAN, YAN |
分类号 |
A61K39/00;A61K39/395;C07K16/28;G01N33/50;G01N33/574;G01N33/68 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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