发明名称 |
DNA VACCINE COMPOSITIONS AND METHODS OF USE |
摘要 |
The present invention is directed to a DNA vaccine for immunization against HIV. The invention comprises a DNA molecule that has a sequence encoding a plurality of viral proteins capable of stimulating an immune response against HIV. The DNA molecule is rendered safe for used as a vaccine by the disruption of genes encoding reverse transcriptase, integrase, and Vif. The DNA molecule is further rendered safe by at least a partial deletion of the 3′ LTR. |
申请公布号 |
EP1667523(B1) |
申请公布日期 |
2012.11.21 |
申请号 |
EP20040784389 |
申请日期 |
2004.09.16 |
申请人 |
UNIVERSITY OF KANSAS MEDICAL CENTER |
发明人 |
NARAYAN, OPENDRA;LIU, ZHENQIAN |
分类号 |
C12N15/867;A01N43/04;A01N63/00;A61K;A61K39/21;A61K48/00;C07H21/04;C12N15/00;C12N15/63;C12N15/86 |
主分类号 |
C12N15/867 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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