| 摘要 |
PURPOSE: A nanoparticle containing a hydrophobic drug in a hyaluronic acid-bile acid complex is provided to ensure excellent anticancer effect and to be used as a novel drug delivery system for treating cancer. CONSTITUTION: A low molecular hyaluronic acid-bile acid complex is an amphiphilic complex in which hydrophobic bile acid is conjugated to low molecular hyaluronic acid and forms a self-aggregation in the water. The hydrophobic bile acid is 5-beta-cholanic acid, cholic acid, chenodeoxycholic acid, glycocholic acid, taurocholic acid, deoxycholic acid, lithocholic acid, or 7-oxo-lithocholic acid. The complex is prepared by covalent bond of amino ethyl 5-beta cholanoamide to the low molecular hyaluronic acid.
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