发明名称 |
Method of enhancing of binding activity of antibody composition to Fcγ receptor IIIa |
摘要 |
A method for enhancing a binding activity of an antibody composition to Fcγ receptor IIIa, which comprises modifying a complex N-glycoside-linked sugar chain which is bound to the Fc region of an antibody molecule; a method for enhancing an antibody-dependent cell-mediated cytotoxic activity of an antibody composition; a process for producing an antibody composition having an enhanced binding activity to Fcγ receptor IIIa; a method for detecting the ratio of a sugar chain in which fucose is not bound to N-acetylglucosamine in the reducing end in the sugar chain among total complex N-glycoside-linked sugar chains bound to the Fc region in an antibody composition; an Fc fusion protein composition produced by using a cell resistant to a lectin which recognizes a sugar chain in which 1-position of fucose is bound to 6-position of N-acetylglucosamine in the reducing end through α-bond in a complex N-glycoside-linked sugar chain; and a process for producing the same. |
申请公布号 |
US8313913(B2) |
申请公布日期 |
2012.11.20 |
申请号 |
US20090550160 |
申请日期 |
2009.08.28 |
申请人 |
NAKAMURA KAZUYASU;SHITARA KENYA;KYOWA HAKKO KIRIN CO., LTD |
发明人 |
NAKAMURA KAZUYASU;SHITARA KENYA |
分类号 |
G01N31/00;A61K39/395;A61P9/00;A61P29/00;A61P31/04;A61P31/12;A61P31/14;A61P35/00;A61P37/02;A61P37/04;A61P37/08;A61P43/00;C07K16/00;C07K16/22;C07K16/28;C07K16/30;C12P21/02;C12P21/08 |
主分类号 |
G01N31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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