<p>This application relates to recombinant human interferon-like proteins. In one embodiment a recombinant protein created by gene shuffling technology is described having enhanced anti-viral and anti-proliferative activities in comparison to naturally occurring human interferon alpha 2b (HuIFN-.alpha.2b). The invention encompasses a polynucleotide encoding the protein and recombinant vectors and host cells comprising the polynucleotide. Preferably the polynucleotide is selected from the group of polynucleotides each having a sequence at least 93% identical to SEQ ID: No. 1 and the protein is selected from the group of proteins each having an amino acid sequence at least 85% identical to SEQ ID No: 2. The proteins and compositions comprising the proteins can be used for treatment of conditions responsive to interferon therapy, such as viral diseases and cancer.</p>
申请公布号
CA2692358(C)
申请公布日期
2012.11.20
申请号
CA20072692358
申请日期
2007.06.22
申请人
NOVAGEN HOLDING CORPORATION
发明人
DU, YONG;LI, JIZHI;LIU, LONGBIN;MAO, CHUNSHENG;WANG, HAITAO;WANG, LING;XU, JING;ZHANG, RUI