ETHYL 1,6-DIARYL-4-AROYL-3-HYDROXY-2-OXO-8-PHENYL-1,7-DIAZASPIRO[4,4]NONA-3,6,8-TRIEN-9-CARBOXILATES AND METHOD OF THEIR OBTAINING

摘要

FIELD: chemistry. ^ SUBSTANCE: invention relates to novel ethyl 1,6-diaryl-4-aroyl-3-hydroxy-2-oxo-8-phenyl-1,7-diazaspiro[4,4]nona-3,6,8-trien-9-carboxilates of formula , where Ar stands for Ph, C6H4Me-4; R stands for C6H4Me-4, C6H4OMe-4, which demonstrate analgesic activity. Compounds are obtained by interaction of 1-aryl-4,5-diaroly-1H-pyrrole-2,3-dione with ethyl ether of 3-amino-3-phenylpropenoic acid with ratio 1:1 in medium of boiling absolute benzene with further separation of target products. ^ EFFECT: method improvement. ^ 4 cl, 1 dwg, 1 tbl, 3 ex