发明名称 |
5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles as inhibitors of Hsp90 chaperone and the intermediates for production thereof |
摘要 |
Invention is related to novel compounds -5-aryl-4-(5-substituted 2,4-dihydroxyphenyl)-1,2,3-thiadiazoles with general formula (I). The compounds can be used in biomedicine as active ingredients in pharmaceutical formulations, because they inhibit Hsp90 chaperone which participate in cancer progression. This invention is also related to new intermediate compounds which are used for the synthesis of thiadiazoles of general formula (I). |
申请公布号 |
US8314132(B2) |
申请公布日期 |
2012.11.20 |
申请号 |
US20080990551 |
申请日期 |
2008.06.18 |
申请人 |
MATULIS DAUMANTAS;CIKOTIENE INGA;KAZLAUSKAS EGIDIJUS;MATULIENE JURGITA;BIOTECHNOLOGIJOS INSTITUTAS |
发明人 |
MATULIS DAUMANTAS;CIKOTIENE INGA;KAZLAUSKAS EGIDIJUS;MATULIENE JURGITA |
分类号 |
A61K31/433;C07C243/18;C07D285/06 |
主分类号 |
A61K31/433 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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