| 摘要 |
A transdermal drug delivery device comprises a reservoir layer (10), which consists of one or more chambers (24) for containing a drug. A lower surface of the reservoir layer (10) is bounded by a resilient membrane (12), which is perforated by pores (26) through which the drug may be delivered from the chambers (24). Connected to the reservoir layer (10) is an extensor means (18), which can be actuated by control means (22) to deform the reservoir layer (10) such that the chambers (24) are compressed and the pores (26) are enlarged, thereby forcing the drug from the chambers (24) through the pores (26) and into contact with the patient~s skin (30). When the resilient membrane (12) is adhered to the skin (30), the extension and relaxation of the device causes simultaneous stretching and relaxation of the skin (30), disrupting the barrier presented by the skin~s surface and enhancing delivery of the drug.
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