APTAMER REGULATED NUCLEIC ACID AND USE THEREOF

摘要

PROBLEM TO BE SOLVED: To couple the ability of RNA-based regulators that can directly target transcripts with allosteric control typically associated with protein-based regulators.

SOLUTION: This nucleic acid comprises (i) a substrate sequence that can form a substrate for extrinsic enzymatic activity, and (ii) an aptamer that binds to a ligand, wherein binding of the ligand to the aptamer causes a conformational change in the nucleic acid that alters the ability of the substrate sequence to form the substrate and/or alters the Km and/or Kcat of the substrate for the extrinsic enzymatic activity.

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