发明名称 |
METHODS OF DISEASE ACTIVITY PROFILING FOR PERSONALIZED THERAPY MANAGEMENT |
摘要 |
The present invention provides methods for personalized therapeutic management of a disease in order to optimize therapy and/or monitor therapeutic efficacy. In particular, the present invention comprises measuring an array of one or a plurality of biomarkers at a plurality of time points over the course of therapy with a therapeutic agent to determine a mucosal healing index for selecting therapy, optimizing therapy, reducing toxicity, and/or monitoring the efficacy of therapeutic treatment. In certain instances, the therapeutic agent is a TNFa inhibitor for the treatment of a TNFa-mediated disease or disorder. |
申请公布号 |
CA2839792(A1) |
申请公布日期 |
2012.11.15 |
申请号 |
CA20122839792 |
申请日期 |
2012.05.10 |
申请人 |
NESTEC S.A. |
发明人 |
SINGH, SHARAT;HOE, NICHOLAS;LOCKTON, STEVE;HAUENSTEIN, SCOTT;OHRMUND, LINDA |
分类号 |
C12Q1/68;G01N33/564;G01N33/68 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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