发明名称 |
HUMAN ANTIBODIES AGAINST HEPATITIS C VIRUS (HCV) AND USES THEREOF |
摘要 |
Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma or in a non-human transgenic animal, e.g., a transgenic mouse, capable of producing multiple isotypes of human monoclonal antibodies by undergoing V-D-J recombination and isotype switching. Also disclosed are pharmaceutical compositions comprising the human antibodies, non-human transgenic animals, and hybridomas which produce the human antibodies, and therapeutic and diagnostic methods for using the human antibodies.
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申请公布号 |
US2012288510(A1) |
申请公布日期 |
2012.11.15 |
申请号 |
US20080527663 |
申请日期 |
2008.02.13 |
申请人 |
AMBROSINO DONNA M.;THOMAS, JR. WILLIAM D.;BABCOCK GREGORY J.;BROERING TERESA;SLOAN SUSAN;UNIVERSITY OF MASSACHUSETTS |
发明人 |
AMBROSINO DONNA M.;THOMAS, JR. WILLIAM D.;BABCOCK GREGORY J.;BROERING TERESA;SLOAN SUSAN |
分类号 |
A61K39/395;A61P31/12;C07K14/02;C07K16/00;C07K16/18;C12N5/00;C12N15/13;C12N15/63;G01N33/53 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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