发明名称 |
Process for Forming Amorphous Atorvastatin |
摘要 |
A process for forming amorphous atorvastatin comprising the steps of dissolving atorvastatin in a non-hydroxylic solvent and removing the solvent by freeze-drying, as well as processes of dissolving atorvastatin in a hydroxylic solvent with a solubilizing agent or an alkalizing agent or an antioxidant and removing the solvent by freeze-drying to afford amorphous atorvastatin. |
申请公布号 |
US2012289576(A1) |
申请公布日期 |
2012.11.15 |
申请号 |
US201213559776 |
申请日期 |
2012.07.27 |
申请人 |
DEBETTENCOURT, III ANTONE J;ROSE PETER R.;SHALAEV EVGENYI;QUALLICH GEORGE J.;ZIEGLER, JR. CARL B.;PFIZER INC |
发明人 |
DEBETTENCOURT, III ANTONE J;ROSE PETER R.;SHALAEV EVGENYI;QUALLICH GEORGE J.;ZIEGLER, JR. CARL B. |
分类号 |
C07D207/34;A61K31/40;A61P3/06;A61P19/10;A61P25/28;A61P35/00 |
主分类号 |
C07D207/34 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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