发明名称 |
MODIFIED BIOTIN-BINDING PROTEIN, FUSION PROTEINS THEREOF AND APPLICATIONS |
摘要 |
The disclosure provides modified biotin-binding proteins which can be expressed in soluble form in high yield in bacteria. Also provided are fusion proteins comprising the modified biotin-binding protein and an antigen. The disclosure further provides non-hemolytic variants of alpha-hemolysin from S. aureus and fusion protein comprising non-hemolytic variant of alpha-hemolysin and a biotin-binding domains. Immunogenic compositions comprising the proteins are also disclosed and use of such immunogenic compositions for inducing an immune response or for vaccinating a subject are also disclosed. |
申请公布号 |
WO2012155053(A1) |
申请公布日期 |
2012.11.15 |
申请号 |
WO2012US37541 |
申请日期 |
2012.05.11 |
申请人 |
CHILDREN'S MEDICAL CENTER CORPORATION;MALLEY, RICHARD;LU, YINGJIE;ZHANG, FAN |
发明人 |
MALLEY, RICHARD;LU, YINGJIE;ZHANG, FAN |
分类号 |
A61K31/00;A61K38/00;A61K39/085;A61P31/00;A61P37/02;A61P37/04 |
主分类号 |
A61K31/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|