ASSAYS FOR DETECTING AUTOANTIBODIES TO ANTI-TNFa DRUGS

摘要

The present invention provides assays for detecting and measuring the presence or level of autoantibodies to anti-TNFa drug therapeutics in a sample. The present invention is useful for optimizing therapy and monitoring patients receiving anti-TNFa drug therapeutics to detect the presence or level of autoantibodies against the drug. The present invention also provides methods for selecting therapy, optimizing therapy, and/or reducing toxicity in subjects receiving anti-TNFa drugs for the treatment of TNFa-mediated disease or disorders.