| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a pharmaceutical product having antiviral activity against new and seasonal human influenza viruses, with a polysaccharide fraction extracted from microalgae coccomyxa as an active ingredient. <P>SOLUTION: Such a polysaccharide fraction that a majority of lipids are removed from microalgae coccomyxa is provided. A method for producing an antiviral agent with the polysaccharide fraction as an active ingredient, is also provided, being characterized by including: a step of conducting ultrasonic shaking and centrifugally separating with microalgae coccomyxa and a volatile solvent combined together; a step of conducting a delipidizing twice or more with a volatile solvent; a step of adding a necessary amount of water thereafter followed by heating for a necessary period of time to conduct a hot-water extraction; and a step of condensing and evaporating to dryness a liquid layer obtained by conducting a solid-liquid separation of the resultant hot-water extract by centrifugal separation. By this method, a majority of lipids can be removed from microalgae coccomyxa thanks to the repeated lipids-removing step, enabling a high-purity extract to be obtained. Because of having high antiviral activity against new and seasonal A-type human influenza viruses, this antiviral agent can be used as a pharmaceutical product. <P>COPYRIGHT: (C)2013,JPO&INPIT |
