| 发明名称 |
PROCESS FOR THE SPECIFIC ISOTOPIC LABELING OF METHYL GROUPS OF VAL, LEU AND ILE |
| 摘要 |
The invention relates to a process for the specific isotopic labeling of Valine, Leucine and Isoleucine amino acids. The process of the invention uses a 2-alkyl-2-hydroxy-3-oxobutanoic acid in which the alkyl substituent in position 2 is ethyl or methyl. The invention can be used for the analysis of proteins, in particular by NMR. |
| 申请公布号 |
EP2521704(A1) |
申请公布日期 |
2012.11.14 |
| 申请号 |
EP20100704415 |
申请日期 |
2010.01.06 |
| 申请人 |
COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIESALTERNATIVES;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSITE JOSEPH FOURIER |
发明人 |
GANS, PIERRE;BOISBOUVIER, JEROME;AYALA, ISABEL;HAMELIN, OLIVIER |
| 分类号 |
C07B59/00;C07C51/367;C07C59/215;C12P13/04;C12P13/06;C12P21/02 |
主分类号 |
C07B59/00 |
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