发明名称 |
Methods for treatment and prevention of tauopathies and amyloid beta amyloidosis by modulating CRF receptor signaling |
摘要 |
Methods for treating or preventing tauopathies and/or A² amyloidosis by modulating CRF receptor signaling. Accumulation of hyperphosphorylated tau protein in the CNS may be reduced by administration of CRF-R1 selective antagonists and/or CRF-R2 selective agonists. For example, in some aspects, methods for preventing the onset of Alzheimer's disease by administration of CRF-R1 selective antagonists are provided. |
申请公布号 |
EP2522351(A1) |
申请公布日期 |
2012.11.14 |
申请号 |
EP20120179553 |
申请日期 |
2008.06.13 |
申请人 |
RESEARCH DEVELOPMENT FOUNDATION |
发明人 |
RISSMAN, ROBERT A.;LEE, KUO-FEN;VALE, WYLIE W.;SAWCHENKO, PAUL E. |
分类号 |
A61K31/519;A61K38/22;A61K38/57;A61K45/06;A61P25/28;G01N33/68 |
主分类号 |
A61K31/519 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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