POLYPEPTIDES AND ANTIBODIES

摘要

179 POLYPEPTIDES AND ANTIBODIES ABSTRACT POLYPEPTICLES ARE PROVIDED. ANTIBODIES OR ANTIGEN BINDING DOMAINS ARE 5 PROVIDED WHICH BIND SUCH POLYPEPTIDES. ALSO PROVIDED ARE METHODS OF OBTAINING AN ANTIBODY THAT BINDS TUMOR NECROSIS FACTOR (TNF)-RELATED APOPTASIS-INDUCING LIGAND ("TRAIL") RECEPTOR-2 JR-2) COMPRISING ADMINISTERING AT LEAST ONE OF SUCH POLYPEPTIDES TO AN ANIMAL AND OBTAINING AN ANTIBODY THAT BINDS TR-2 FROM THE ANIMAL. ANTIBODIES REACTIVE WITH TR-2 ARE 1 0 PROVIDED. ALSO PROVIDED ARE CELLS PRODUCING ANTIBODIES REACTIVE WITH TR-2, PHARMACEUTICAL COMPOSITIONS COMPRISING ANTIBODIES REACTIVE WITH TR-2, METHODS USING ANTIBODIES REACTIVE WITH TR-2, AND KITS COMPRISING ANTIBODIES REACTIVE WITH TR-2. ALSO PROVIDED ARE METHODS OF DECREASING OR PREVENTING BINDING OF AN ANTIBODY TO TR-2 BY ADMINISTERING SUCH A POLYPEPTICLE. 15