发明名称 |
Compositions for modulating a kinase cascade and methods of use thereof |
摘要 |
The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.
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申请公布号 |
US8309549(B2) |
申请公布日期 |
2012.11.13 |
申请号 |
US201113094679 |
申请日期 |
2011.04.26 |
申请人 |
HANGAUER, JR. DAVID G.;PATRA DEBASIS;CODY JEREMY A.;PALMER GRANT J.;ISBESTER PAUL K.;SALSBURY JONATHON;KINEX PHARMACEUTICALS, LLC |
发明人 |
HANGAUER, JR. DAVID G.;PATRA DEBASIS;CODY JEREMY A.;PALMER GRANT J.;ISBESTER PAUL K.;SALSBURY JONATHON |
分类号 |
A61K31/5377;C07D413/12 |
主分类号 |
A61K31/5377 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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