PROCESS FOR THE PRODUCTION OF 3-OXO-PREGNANE-21,17-CARBOLACTONES AND 3-OXO-PREGN-4-ENE-21,17-CARBOLACTONES, HEMISOLVATE, PROCESS FOR THE PREPARATION THEREOF AND PROCESS FOR THE PRODUCTION OF DROSPIRENONE

摘要

This invention relates to processes for the production of 3-oxo-pregnane-21,17-carbolactones of formula (II) as well as 3-oxo-pregn-4-ene-21,17-carbolactones of formula (III) by the metal-free oxidation of 17-(3-hydroxypropyl)-3,17-dihydroxyandrostanes of formula (I). In addition, the invention relates to the dichloromethane hemisolvate of 6β,7β;15β,16β-dimethylene-3-oxo-17α-pregnan-5β-ol-21,17-carbolactone (IV) as such as well as to a process for the production of drospirenone.IIIIIIIV