发明名称 |
ANTI-MICROBIAL AGENTS AND COMPOSITIONS AND METHODS OF PRODUCTION AND USE THEREOF |
摘要 |
Anti-microbial compositions for inhibiting gram-negative bacterial growth include inhibitors of one or more interactions between the bacterial proteins TonB and ExbD and/or between the bacterial proteins TolR and TolA. Methods of producing and using the anti-microbial compositions (e.g., treating gram-negative bacterial infections in a mammalian subject) are described. Novel antibiotics that target the TonB system and prevent bacterial growth are described herein. |
申请公布号 |
WO2012112438(A3) |
申请公布日期 |
2012.11.08 |
申请号 |
WO2012US24851 |
申请日期 |
2012.02.13 |
申请人 |
THE PENN STATE RESEARCH FOUNDATION;POSTLE, KATHLEEN |
发明人 |
POSTLE, KATHLEEN |
分类号 |
A61K38/08;A61K35/66;A61K35/74;A61P31/00;A61P31/04 |
主分类号 |
A61K38/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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