| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a specific and new tumor marker capable of achieving early diagnosis of small cell lung cancer. <P>SOLUTION: As a result of performing proteome analysis of protein/peptide discharged to culture supernatant of a cultured cell line derived from a human lung cancer in order to search tumor marker candidate substances useful for diagnosis of early-stage lung cancer, such a result that proNT/NMN (proNeurotensin/Neuromedin N) is discharged to the culture supernatant of SBC3 to be a cultivated cell line of the small cell lung cancer but the proNT/NMN is not detected on the culture supernatant of lung cancer cell lines (adenocarcinoma, large cell cancer, squamous cell carcinoma) other than the small cell lung cancer is found out. Consequently, the small cell lung cancer can be diagnosed by measuring the manifestation amount of the proNT/NMN in a biological sample collected from human being by a primer set or a probe for detecting existence of the proNT/NMN. <P>COPYRIGHT: (C)2013,JPO&INPIT |
