发明名称 |
BETA-HAIRPIN PEPTIDOMIMETICS |
摘要 |
&bgr;-Hairpin peptidomimetics of the general formula Cyclo(-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-Xaa14-Xaa15-Xaa16-), and pharmaceutically acceptable salts thereof, with Xaa 1-Xaa 16 being amino acid residues of certain types which are defined in the description and the claims, have CXCR4 antagonizing properties and prolonged half-lives in vivo and can be used for preventing HIV infections in healthy individuals or for slowing and halting viral progression in infected patients; or where cancer is mediated or resulting from CXCR4 receptor activity; or where immunological diseases are mediated or resulting from CXCR4 receptor activity; or for treating immunosuppression; or during apheresis collections eases of peripheral blood stem cells and/or as agents to induce mobilization of stem cells to regulate tissue repair. These peptidomimetics can be manufactured by a process which is based on a mixed solid-and solution phase synthetic strategy. |
申请公布号 |
US2012283196(A1) |
申请公布日期 |
2012.11.08 |
申请号 |
US200913513550 |
申请日期 |
2009.12.04 |
申请人 |
POLYPHOR AG |
发明人 |
BARTHELEMY SOPHIE;BISANG CHRISTIAN;GOMBERT FRANK OTTO;LEDERER ALEXANDER;OBRECHT DANIEL;ROMAGNOLI BARBARA;ZUMBRUNN JUERG;REMUS TOBIAS;LEMERCIER GUILLAUME |
分类号 |
C07K7/64;A61K38/12;C07K1/06 |
主分类号 |
C07K7/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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