Compositions and methods for treating cancer are described. Some of the methods include administering to a cancer patient in need thereof a substance, such as a carbonic anhydrase inhibitor, that at a therapeutic dose produces a metabolic acidosis in humans; and administering to the patient at least one of: (a) a monocarboxylate transport inhibitor; (b) a sodium-hydrogen exchange inhibitor; (c) a chloride-bicarbonate exchange inhibitor; or (d) a proton pump inhibitor; wherein the at least one of (a) through (d) is in an amount effective to induce selective cytotoxicity in cancer cells relative to noncancerous cells in humans.
申请公布号
WO2012151559(A2)
申请公布日期
2012.11.08
申请号
WO2012US36676
申请日期
2012.05.04
申请人
ROSE PHARMACEUTICALS, LLC;ROSENBERG, MARK, A.;HILL, JAMES, W.