METHODS OF DEVELOPING A PROGNOSIS FOR PANCREATIC CANCER AND PREDICTING RESPONSIVENESS TO CANCER THERAPEUTICS
摘要
Methods of predicting responsiveness of a cancer in a subject to a cancer therapy including a VEGF targeting agent are provided herein. The methods include detecting the expression level of at least one biomarker selected from ANG-2, SDF-1 and VEGF-D in a sample from the subject and using the expression levels to determine whether the VEGF targeting agent will be effective to treat the cancer in the subject. The predictions may be used to develop treatment plans for the subjects. Methods of developing a prognosis for a subject with pancreatic cancer are also provided. These methods include determining the expression level of IGFBP-1, PDGF-AA and at least one of IL-6 or CRP in a sample from a subject with pancreatic cancer.
申请公布号
WO2012151574(A1)
申请公布日期
2012.11.08
申请号
WO2012US36779
申请日期
2012.05.07
申请人
DUKE UNIVERSITY;NIXON, ANDREW, B.;HURWITZ, HERBERT, I.;PANG, HERBERT;STARR, MARK, D.
发明人
NIXON, ANDREW, B.;HURWITZ, HERBERT, I.;PANG, HERBERT;STARR, MARK, D.