摘要 |
A number of FTY720-derived compounds with antitumor activity are described. These compounds include the compounds of formula (I) wherein R1 is independently selected from the group consisting of hydrogen, methyl, methoxy, and hydroxyl; R2 is independently selected from the group consisting of hydrogen, methoxy, and hydroxyl; R3 is independently selected from the group consisting of alkyl and cyclo-alkyl; and n is independently selected from 0 to 6. The compounds have lower immunosuppressive side effects as a result of not being phosphorylated by sphingosine kinase 2. |
申请人 |
THE OHIO STATE UNIVERSITY RESEARCH FOUNDATION;CHEN, CHING-SHIH;KULP, SAMUEL, K.;WANG, DASHENG;BYRD, JOHN, C.;MUTHUSAMY, NATARAJAN |
发明人 |
CHEN, CHING-SHIH;KULP, SAMUEL, K.;WANG, DASHENG;BYRD, JOHN, C.;MUTHUSAMY, NATARAJAN |