| 摘要 |
Antibody formulations are described comprising a mixture of an anti-a4ß7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-a4ß7 antibody in vivo. |
| 申请人 |
MILLENNIUM PHARMACEUTICALS, INC.;DILUZIO, WILLOW;NGUYEN, PHUONG M.;VARGA, CSANAD M.;PALANIAPPAN, VAITHIANATHAN;BROWN, JASON;FOX, IRVING H.;SCHOLZ, CATHERINE;JENKINS, HELEN;ROSARIO, MARIA |
发明人 |
DILUZIO, WILLOW;NGUYEN, PHUONG M.;VARGA, CSANAD M.;PALANIAPPAN, VAITHIANATHAN;BROWN, JASON;FOX, IRVING H.;SCHOLZ, CATHERINE;JENKINS, HELEN;ROSARIO, MARIA |
