| 摘要 |
<P>PROBLEM TO BE SOLVED: To provide a formulation of live therapeutic viruses and live virus vaccines. <P>SOLUTION: Envelope viruses (e.g., Newcastle disease virus (NDV)) are formulated for storage at moderately cold temperatures (e.g., -20°C). The formulation is an aqueous solution containing the enveloped virus at a concentration of from 10<SP POS="POST">6</SP>PFU/mL to 10<SP POS="POST">12</SP>PFU/mL; and a non-reducing saccharide (e.g., sucrose). When the non-reducing saccharide is a disaccharide it is present in the solution at a concentration of from 5% (w/v) to 50% (w/v), and when it is a monosaccharide it is present in the solution at a concentration of from 2.5% (w/v) to 25% (w/v). The solution has an osmotic pressure of about 250 mOs or higher, and has a pH of from 5 to 10. <P>COPYRIGHT: (C)2013,JPO&INPIT |
