发明名称 |
ANTI-GLYPICAN-3 ANTIBODY HAVING IMPROVED KINETICS IN PLASMA |
摘要 |
<p>A method of modulating the plasma half-life of anti-glypican 3 antibody, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody that has a plasma half-life that has been modulated, a method of preparing the anti-glypican 3 antibody and a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient are provided. Disclosed is a method of modulating the plasma half-life of anti-glypican 3 antibody by modifying an amino acid residue that is exposed on the surface of the anti-glypican 3 antibody; and anti-glypican 3 antibody that has a plasma half-life that has been modulated by amino acid residue modification, a pharmaceutical composition comprising as an active ingredient the anti-glypican 3 antibody, and a method of preparing the anti-glypican 3 antibody and producing a pharmaceutical composition comprising the anti-glypican 3 antibody as an active ingredient.</p> |
申请公布号 |
EP2196541(B1) |
申请公布日期 |
2012.11.07 |
申请号 |
EP20080834671 |
申请日期 |
2008.09.26 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA |
发明人 |
IGAWA, TOMOYUKI;KURAMOCHI, TAICHI;SHIRAIWA, HIROTAKE;TSUNODA, HIROYUKI;TACHIBANA, TATSUHIKO;ISHIGURO, TAKAHIRO |
分类号 |
C12P21/08;A61K39/395;A61P35/00;C07K16/30;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/09 |
主分类号 |
C12P21/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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