| 摘要 |
PURPOSE: An imidazole-based alkaloid derivative, a pharmaceutically acceptable salt thereof and a method for preparing the same are provided to suppress HIF-1 activation and angiogenesis and to treat diseases related to angiogenesis. CONSTITUTION: An imidazole-based alkaoid derivative is denoted by chemical formula 1. A method for preparing the compound of chemical formula 1 comprises: a step of reacting a compound of chemical formula 1 and a compound of chemical formula 3 to prepare a compound of chemical formula 4; a step of reducing the compound of chemical formula 4 and halogenations of alcohol to prepare a compound of chemical formula 5; a step of reacting a compound of chemical formula 5 with a compound of chemical formula 6. A composition for angiogenesis suppression and antioxidation contains: pharmaceutically effective amount of compounds of chemical formula 1, pharmaceutically acceptable salt, hydrate, solvate, isomer, or prodrug thereof; and a pharmaceutically acceptable carrier, diluents, or excipient or a combination thereof.
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