发明名称 |
Pharmacogenomics of blood pressure lowering agents |
摘要 |
A method of determining a suitable blood pressure lowering treatment for an individual comprises a step of assaying a biological sample from the individual for the presence or absence of the C-5312T SNP in a distal enhancer region of the renin gene. The presence of at least one T allele is indicative of an increased response to a blood pressure lowering treatment selected from the group comprising: angiotensin-2-receptor blockers; ACE Inhibitors; aldosterone receptor blockers; and beta-receptor blockers. The absence of at least one T allele is indicative of an increased response to a blood pressure lowering treatment selected from the group comprising: renin inhibitors; calcium channel blockers; and diuretics. |
申请公布号 |
US8304190(B2) |
申请公布日期 |
2012.11.06 |
申请号 |
US20060883520 |
申请日期 |
2006.02.02 |
申请人 |
STANTON ALICE;MOORE NIAMH;ROYAL COLLEGE OF SURGEONS IN IRELAND |
发明人 |
STANTON ALICE;MOORE NIAMH |
分类号 |
C12Q1/68;A61P9/12 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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