发明名称 |
Compounds and methods for treating inflammatory and fibrotic disorders |
摘要 |
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
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申请公布号 |
US8304413(B2) |
申请公布日期 |
2012.11.06 |
申请号 |
US20090477715 |
申请日期 |
2009.06.03 |
申请人 |
KOSSEN KARL;SEIWERT SCOTT D.;SEREBRYANY VLADIMIR;RUHRMUND DONALD;BEIGELMAN LEONID;RAVEGLIA LUCA FRANCESCO MARIO;VALLESE STEFANIA;BIANCHI IVANA;HU TAO;INTERMUNE, INC. |
发明人 |
KOSSEN KARL;SEIWERT SCOTT D.;SEREBRYANY VLADIMIR;RUHRMUND DONALD;BEIGELMAN LEONID;RAVEGLIA LUCA FRANCESCO MARIO;VALLESE STEFANIA;BIANCHI IVANA;HU TAO |
分类号 |
A61K31/50;A61K31/437;A61K31/44;A61K31/497 |
主分类号 |
A61K31/50 |
代理机构 |
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地址 |
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