发明名称 |
Compositions and methods relating to proteins requiring gamma-carboxylation |
摘要 |
The present invention relates a host cell comprising an expression vector comprising a nucleic acid molecule encoding a protein requiring gamma-carboxylation and associated expression control sequences and a nucleic acid molecule encoding a vitamin K epoxido reductase and associated expression control sequences and a nucleic acid molecule encoding a γ-glutamyl carboxylase and associated control sequences. The invention further relates to a method of producing a protein requiring gamma-carboxylation in high yields. |
申请公布号 |
US8304224(B2) |
申请公布日期 |
2012.11.06 |
申请号 |
US201113167134 |
申请日期 |
2011.06.23 |
申请人 |
LOEVGREN ANN;MEDIMMUNE LIMITED |
发明人 |
LOEVGREN ANN |
分类号 |
C12N1/20;C07H21/04;C07K1/00;C12N9/00;C12N9/02;C12N9/14;C12N15/00;C12P21/04;C12Q1/00;C12Q1/68 |
主分类号 |
C12N1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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