发明名称 |
Methylated heparin-binding hemagglutinin recombinant mycobacterial antigen, preparation method and immunogenic compositions comprising same |
摘要 |
The invention concerns a methylated immunogenic recombinant peptide sequence comprising mycobacterial heparin-binding hemagglutinin. The invention also concerns chemical and enzymatic methods for preparing such a sequence, the sequence being previously produced in a non-methylated recombinant form then methylated by post-translational modification. The invention further concerns recombinant tools, vectors and host cells for implementing post-translational enzymatic methylation of the recombinant HBHA. The invention finally concerns immunogenic compositions comprising methylated, native or recombinant HBHA, such compositions being useful for preparing vaccines against mycobacterial infections. |
申请公布号 |
US8303963(B2) |
申请公布日期 |
2012.11.06 |
申请号 |
US20100895185 |
申请日期 |
2010.09.30 |
申请人 |
PETHE KEVIN;MENOZZI FRANCO;LOCHT CAMILLE;INSTITUT PASTEUR DE LILLE;UNSTITUT NATIONAL DE LA SANTE ET DE LA RECHERECHEMEDICALE |
发明人 |
PETHE KEVIN;MENOZZI FRANCO;LOCHT CAMILLE |
分类号 |
A61K39/04;C12N15/09;A61K39/02;A61K39/39;A61K49/00;A61P31/06;C07K14/35;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12P21/02 |
主分类号 |
A61K39/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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