发明名称 |
Radiolabeled affibody molecules |
摘要 |
The invention provides a radiolabeled affibody molecule comprising a fragment of an IgG-binding domain of protein A from Staphylococcus aureus, a bifunctional linker, and a radiolabel comprising 18F or 76Br, wherein the bifunctional linker links the fragment and the radiolabel. The affibody molecule binds with high affinity to select receptors, which are over-expressed in certain cancers. Since the radionuclides emit a positron, the in vitro and in vivo binding characteristics of the radiolabeled affibody can be assessed using diagnostic imaging. |
申请公布号 |
US8303960(B2) |
申请公布日期 |
2012.11.06 |
申请号 |
US20080528823 |
申请日期 |
2008.02.27 |
申请人 |
CAPALA JACEK;KIESEWETTER DALE O.;KRAMER-MAREK GABRIELA;LEE SANG BONG;THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
CAPALA JACEK;KIESEWETTER DALE O.;KRAMER-MAREK GABRIELA;LEE SANG BONG |
分类号 |
A61K51/08;A61K38/16;A61K51/00;C07K16/00 |
主分类号 |
A61K51/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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