PROCESS FOR PRODUCING MONATIN

摘要

The present invention provides: a process for producing 2R,4R-monatin with good yield not using an expensive starting material D-Trp but using an inexpensive starting material L-Trp; and others. Specifically, the present invention provides: a process for producing 2R,4R-monatin or a salt thereof, which comprises the steps (1) to (3) mentioned below; and others. (1) A step of bringing L-tryptophan into contact with a deaminase to produce indole-3-pyruvic acid; (2) a step of bringing indole-3-pyruvic acid and pyruvic acid into contact with aldolase to produce 4R-IHOG; and (3) a step of bringing 4R-IHOG into contact with a D-aminotransferase in the presence of a D-amino acid to produce 2R,4R-monatin. In the step (3), it is preferred to use a D-aminotransferase that does not have an ability of producing D-tryptophan from indole-3-pyruvic acid or is reduced in the ability.