发明名称 |
HOMODIMER OF INSULINOTROPIC PEPTIDE ANALOGUES AND METHOD FOR PREPARATION THEREOF AND USE THEREOF |
摘要 |
Provided is a homodimer of insulinotropic peptide analogues and method for preparation thereof and use thereof, wherein the insulinotropic peptide analogue comprises GLP-1 and Exendin-4. The homodimer of insulinotropic peptide analogues of the invention is made by conjugating two identical insulinotropic peptide analogue molecules at the C-terminal Cys residues via disulfide bond or PEG molecule. The homodimer of insulinotropic peptide analogues of the invention has superior stability and biological activity in vivo, and prolonged half-life in the circulation, and can be used for the preparation of hypoglycemic drugs.
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申请公布号 |
US2012277154(A1) |
申请公布日期 |
2012.11.01 |
申请号 |
US201013391097 |
申请日期 |
2010.03.15 |
申请人 |
FAN KAI;ZHAO ZHIQUAN;CHEN YONG;ZHANG CHUN;WANG LIN;CHONGQING FAGEN BIOMEDICAL INC. |
发明人 |
FAN KAI;ZHAO ZHIQUAN;CHEN YONG;ZHANG CHUN;WANG LIN |
分类号 |
C07K19/00;A61K38/26;A61P3/00 |
主分类号 |
C07K19/00 |
代理机构 |
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主权项 |
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地址 |
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