发明名称 |
ASSAY FOR SHIP1 EXPRESSION, ACTIVITY AND SEQUENCE ALTERATIONS AS A PREDICTOR OF INFLAMMATORY BOWEL DISEASE RISK |
摘要 |
<p>The present disclosure is directed to detecting colon disorders by measuring the expression of SHIP1 in a sample of PBMCs. One method includes the following steps, obtaining a sample including peripheral blood mononuclear cells (PBMCs) from a subject and determining whether SHIP1 is underexpressed in the PBMCs or lacks normal enzymatic activity. The present disclosure is also directed to a method of determining the expression of SHIP1 protein expression and SHIP1 enzyme activity in PBMCs. This method includes the following steps, obtaining a sample comprising PBMCs from a subject and determining the amount of SHIP1 in the PBMCs.</p> |
申请公布号 |
WO2012149323(A1) |
申请公布日期 |
2012.11.01 |
申请号 |
WO2012US35461 |
申请日期 |
2012.04.27 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK;ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM;KERR, WILLIAM G.;FUHLER, GWENNY M.;FERNANDES, SANDRA |
发明人 |
KERR, WILLIAM G.;FUHLER, GWENNY M.;FERNANDES, SANDRA |
分类号 |
G01N33/49;C12Q1/42;G01N33/50;G01N33/573 |
主分类号 |
G01N33/49 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|