OXAZINE DERIVATIVE AND BACE 1 INHIBITOR CONTAINING SAME

摘要

Provided is a compound, for example a compound represented by formula (I), or a pharmaceutically acceptable salt of the same, which has amyloid ß production inhibitory activity, has, in particular, BACE1 inhibitor activity, and can be used as an agent for the treatment or prevention of diseases induced by the production, secretion and/or deposition of amyloid ß protein. (In the formula, -X= is CR7= or -N=, ring B is a substituted or unsubstituted carbon ring or a substituted or unsubstituted heterocyclic ring, R1 is a substituted or unsubstituted alkyl or similar, R2a and R2b are each independently a hydrogen and a substituted or unsubstituted alkyl or similar, R3 and R4 are each independently a hydrogen, a halogen, a substituted or unsubstituted alkyl or similar, R5 is a hydrogen or a substituted or unsubstituted alkyl or similar, R6 is independently a halogen, a hydroxy, a substituted or unsubstituted alkyl or similar, R7 is a hydrogen, a halogen, a hydroxy, a substituted or unsubstituted alkyl or similar, and p is an integer 1-3.)