发明名称 |
COMPOSITIONS AND METHODS FOR DETECTING AND TREATING CANCER |
摘要 |
The invention provides methods for detecting the presence of cancer initiating cells in a tissue, methods for identifying test agent for reducing cancer, and methods for reducing cancer in a subject. The invention's methods are applicable to any cancer, and in particular to liver cancer. The invention also provides the isolation and characterization of pre-malignant hepatocellular carcinoma initiating cells (HICs). The invention further provides methods for isolating hepatocellular carcinoma initiating cells (HICs), methods for using the isolated cells for screening anti-cancer drugs, methods for using HIC markers for the early diagnosis of hepatocellular carcinoma, and methods for the prevention and/or delay of hepatocellular carcinoma by using agents that selectively deplete the number and/or malignant properties of HICs. |
申请公布号 |
WO2012118806(A3) |
申请公布日期 |
2012.11.01 |
申请号 |
WO2012US26943 |
申请日期 |
2012.02.28 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;KARIN, MICHAEL;HE, GUOBIN |
发明人 |
KARIN, MICHAEL;HE, GUOBIN |
分类号 |
C12N5/09;C12N15/12;G01N33/15;G01N33/574 |
主分类号 |
C12N5/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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