发明名称 |
Method of Increasing Intratumoral pHe and Reducing Acid-Mediated Invasion |
摘要 |
A method of treating cancer or inhibiting metastasis in a subject by increasing intratumoral extracellular pH is presented. The method includes administering to the subject a therapeutically effective amount of a buffer having a pKa greater than 6.1. In an advantageous embodiment the pKa of the buffer is about 7.0. Examples of buffers for increasing extracellular pH include NaHCO3, 2-imidazole-1-yl-3-ethoxycarbonylpropionic acid (IEPA), cholamine chloride, N,N-Bis(2-hydroxyethyl)-2-aminoethanesulfonic acid (BES), N-Tris(hydroxymethyl)methyl-2-aminoethanesulfonic acid (TES) and 4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid (HEPES). The method can further include the step of pretreating with one or more chemotherapeutic agents.
|
申请公布号 |
US2012277245(A1) |
申请公布日期 |
2012.11.01 |
申请号 |
US201213479638 |
申请日期 |
2012.05.24 |
申请人 |
GILLIES ROBERT J.;MORSE DAVID L.;SILVA ARIOSTO SIQUEIRA;IBRAHIM HASHIM ARIG A.;GATENBY ROBERT A.;MARTINEZ GARY;H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. |
发明人 |
GILLIES ROBERT J.;MORSE DAVID L.;SILVA ARIOSTO SIQUEIRA;IBRAHIM HASHIM ARIG A.;GATENBY ROBERT A.;MARTINEZ GARY |
分类号 |
A61K31/185;A61K31/14;A61K31/198;A61K31/4172;A61K31/495;A61P35/00;A61P35/04 |
主分类号 |
A61K31/185 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|