发明名称 |
PROCESS FOR PREPARING CREATINE AMIDES |
摘要 |
The invention relates to the field of pharmaceutical chemistry, specifically to processes for preparing biologically active substances (BAS), in particular creatine amides. What is proposed is a process for preparing creatine amides which comprises treating creatine with para-toluenesulfonic acid in an organic solvent with subsequent reaction of the resultant complex with compounds comprising a primary or secondary amino group in the presence of a condensing agent and a base which are introduced subsequently. The claimed process makes it possible to increase the yield of the end product by 2-5 times in comparison with analogs and also to extend the range of the compounds prepared.
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申请公布号 |
US2012277459(A1) |
申请公布日期 |
2012.11.01 |
申请号 |
US201013261286 |
申请日期 |
2010.09.28 |
申请人 |
BUROV SERGEJ VLADIMIROVICH;VESELKINA OLGA SERGEEVNA;LEKO MARIA VICTOROVNA |
发明人 |
BUROV SERGEJ VLADIMIROVICH;VESELKINA OLGA SERGEEVNA;LEKO MARIA VICTOROVNA |
分类号 |
C07C257/10 |
主分类号 |
C07C257/10 |
代理机构 |
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地址 |
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