发明名称 |
PRODUCTION AND DELIVERY OF A STABLE COLLAGEN |
摘要 |
Improved methods are provided for the recombinant synthesis of collagen, particularly collagen VII, in host cell, and for therapeutic delivery of the same. The recombinant collagen is produced in a host cell that has increased levels of prolyl-4-hydroxylase, relative to basal cell levels. The collagen produced by the methods of the invention has increased numbers of modified proline residues, relative to a recombinant collagen produced in a host cell having basal levels of prolyl-4-hydroxylase. The increased proline modification provides for a collagen having increased stability, including increased in vivo stability. |
申请公布号 |
WO2012149136(A1) |
申请公布日期 |
2012.11.01 |
申请号 |
WO2012US35177 |
申请日期 |
2012.04.26 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY;DEPARTMENT OF VETERANS AFFAIRS;MARINKOVICH, M. PETER;LANE, ALFRED T.;RAJADAS, JAYAKUMAR |
发明人 |
MARINKOVICH, M. PETER;LANE, ALFRED T.;RAJADAS, JAYAKUMAR |
分类号 |
A01N37/12;A01N37/44;A61K31/195 |
主分类号 |
A01N37/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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