发明名称 |
ENV POLYPEPTIDE COMPLEXES AND METHODS OF USE |
摘要 |
Provided herein are small molecule CD4 mimetics effective to bind to HIV Env proteins. A CD4 mimetic of the invention, when bound to an Env protein, is effective to induce a conformational change in the Env protein such that cyptic epitopes on the Env protein are exposed. Also provided herein are related methods of identifying and using such small molecule CD4 mimetics, for example, to elicit an immune response in a subject upon administration. |
申请公布号 |
US2012276141(A1) |
申请公布日期 |
2012.11.01 |
申请号 |
US201213492219 |
申请日期 |
2012.06.08 |
申请人 |
SRIVASTAVA INDRESH K.;SHARMA VICTORIA;BARNETT SUSAN W.;ULMER JEFFREY |
发明人 |
SRIVASTAVA INDRESH K.;SHARMA VICTORIA;BARNETT SUSAN W.;ULMER JEFFREY |
分类号 |
A61K39/21;A61P37/04;C07K14/16;C07K14/705;C07K14/73;C07K16/10;C07K16/28 |
主分类号 |
A61K39/21 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|