发明名称 |
MONOCLONAL ANTIBODIES AGAINST CD30 LACKING IN FUCOSYL AND XYLOSYL RESIDUES |
摘要 |
The invention pertains to anti-CD30 antibodies that lack fucosyl and xylosyl residues. The antibodies of the invention exhibit increased antibody-dependent cellular cytotoxicity (ADCC) activity, including the ability to lyse CD30-expressing cell lines that are not lysed by the fucosylated and xylosylated form of the antibodies. The invention also provides host cells that express the anti-CD30 antibodies that lack fucosyl and xylosyl residues, wherein the host cells are deficient for a fucosyltransferase and a xylosyltransferase. Methods of using the antibodies to inhibit the grown of CD30+ cells, such as tumor cells, are also provided. |
申请公布号 |
US2012276086(A1) |
申请公布日期 |
2012.11.01 |
申请号 |
US201213449417 |
申请日期 |
2012.04.18 |
申请人 |
BLACK AMELIA NANCY;PASSMORE DAVID B.;SRINIVASAN MOHAN;DICKEY LYNN F.;COX KEVIN M.;PEELE CHARLES G.;WANG MING-BO;MEDAREX, INC.;BIOLEX THERAPEUTICS, INC. |
发明人 |
BLACK AMELIA NANCY;PASSMORE DAVID B.;SRINIVASAN MOHAN;DICKEY LYNN F.;COX KEVIN M.;PEELE CHARLES G.;WANG MING-BO |
分类号 |
C07K16/28;A61K35/00;A61K39/395;A61P35/02;A61P37/04;C12N5/071;C12N5/10 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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