发明名称 |
GENETICALLY DETERMINED MOUSE MODEL OF RESISTANCE TO TRANSPLANTABLE CANCERS |
摘要 |
We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden and is effective against cell lines from multiple types of cancer. During spontaneous regression or immediately following exposure, cancer cells provoke a massive infiltration of host leukocytes which form aggregates and rosettes with tumor cells. The cytolytic destruction of cancer cells by innate leukocytes is rapid and specific without apparent damage to normal cells. The mice are healthy, cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance that may have potential for therapy or prevention of cancer. |
申请公布号 |
US2012276013(A1) |
申请公布日期 |
2012.11.01 |
申请号 |
US201213535824 |
申请日期 |
2012.06.28 |
申请人 |
CUI ZHENG;WILLINGHAM MARK C. |
发明人 |
CUI ZHENG;WILLINGHAM MARK C. |
分类号 |
A01K67/027;A61K49/00;C12N5/06;C12N5/09 |
主分类号 |
A01K67/027 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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